Daily Archives: February 14, 2011

Synthesis: Copper-mediated trifluoromethylation


The introduction of fluorine in the course of a lead optimisation programme has become a key tool in the medicinal chemist’s armoury and many drug candidates incorporate one or more fluorine atoms.  Two reviews published in 2008 in J.Med.Chem. and … Continue reading

Posted in Med Chem Strategy, Synthesis | Tagged , , , , | 2 Comments