Tag Archives: crystal packing

Improving Solubility using X-ray crystal structure data

A recent publication from AstraZeneca provides a really interesting overview of the approach that they took to optimise the solubility of a series of GPR119 agonists. The initial lead compound 2 was only poorly soluble but, by obtaining small molecule … Continue reading

Posted in GPCR ligands, Med Chem Strategy | Tagged , , , | 6 Comments

Enhancing solubility by disrupting crystal packing

Drug candidates can be classified, according to the BCS system, into four groups on the basis of their permeability and aqueous solubility.  Molecules with lower solubility tend to be more difficult to develop and are subject to closer scrutiny by … Continue reading

Posted in Med Chem Strategy, Reviews | Tagged , , , , , , , , | 6 Comments