Tag Archives: Pain

Working with Ion Channels


Two recent publications highlight the challenges inherent in the targeting of voltage-gated and ion-gated ion channels.  It is only in relatively recent times that technological advances (e.g. higher throughput patch-clamping) have opened up many of these targets to drug discovery … Continue reading

Posted in Ion Channel Blockers, Med Chem Strategy | Tagged , , , , , , , , , , , , , | 2 Comments

Discovery of PF-04457845 (FAAH Inhibitor)


In this latest publication from the Pfizer labs, the authors describe their continuing efforts to identify urea-based, irreversible inhibitors of fatty acid amide hydrolase (FAAH).  Inhibition of FAAH and the concomitant elevation of endogenous levels of fatty acid amides has … Continue reading

Posted in Clinical Candidates, Enzyme Inhibitors | Tagged , , , , , , , , , , , | Leave a comment