Tag Archives: PPB

Optimization of plasma protein binding (again…)


Following hot on the heels of the Pfizer paper we blogged recently, comes a very similar publication from scientists at Genentech/Depomed.  Titled ‘Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?’, the authors highlight the apparent … Continue reading

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Efficacy and plasma protein binding


The December issue of Nature Reviews|Drug Discovery includes an informative article from scientists at Pfizer titled ‘The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery’.  In it they discuss the ways in which plasma protein … Continue reading

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