Tag Archives: toxicity

Drug discovery approaches to minimise drug induced liver injury in man

The recent literature has seen a flurry of papers describing the issue of, and potential approaches to minimising the incidence of, drug-induced liver injury (DILI) in the clinic.   It is well recognised that attrition throughout the development pipeline is often … Continue reading

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Review: Chemical carcinogenicity and mutagenicity

A new review, titled ‘Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology’ , collates the experimentally derived mechanistic knowledge relating to this type of chemically induced toxicity.  Whilst a lot of the material is well … Continue reading

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Structural Alert: Benzimidazoles

An informative letter, just published by a team from Novartis, highlights the risk of suitably substituted benzimidazoles acting as latent precursors to reactive ortho-iminoquinone species.  The example they report (see structure on left below) was Ames positive and exhibited time-dependent inhibition … Continue reading

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