Tag Archives: gpcr

GPCR structure and modeling

Posted on April 18, 2011 by mcb

A recently published letter from scientists at Boehringer Ingelheim nicely summarizes recent advances in our understanding of G protein-coupled receptor (GPCR) structure and function. X-ray structures of the inactive forms of bovine rhodopsin (2000), β2 adrenergic receptor (2007 – with antibody … Continue reading →

Posted in Computational Methods, GPCR ligands | Tagged , , , , , , , , , , | 1 Comment

Discovery of PF-232798 (CCR5 Antagonist)

Posted on January 6, 2011 by mcb

CCR5 antagonists prevent entry of HIV into host cells by binding to the CCR5 co-receptor and stopping the gp120-CD4 complex from making the crucial interaction with CCR5 that leads to fusion of the viral and host cell membranes (see Wikipedia article … Continue reading →

Posted in Clinical Candidates, GPCR ligands | Tagged , , , , , , , , , , , , , , , , , | Leave a comment