Tag Archives: bioactivation

Reducing bioactivation potential by chemical design

Posted on February 25, 2011 by mcb

Continuing the theme of an earlier post, an excellent article in Current Topics in Medicinal Chemistry looks at the issue of adverse drug events associated with the formation of reactive intermediates.  The authors (from Novartis) give some background to drug-related … Continue reading →

Posted in Med Chem Strategy, Reviews, Software, Toxicology | Tagged , , , , , , , , , , , | 1 Comment

Review: Chemical carcinogenicity and mutagenicity

Posted on February 11, 2011 by mcb

A new review, titled ‘Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology’ , collates the experimentally derived mechanistic knowledge relating to this type of chemically induced toxicity.  Whilst a lot of the material is well … Continue reading →

Posted in Toxicology | Tagged , , , , , , | 1 Comment