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Tag Archives: protease
Discovery of MK-1220 (Hepatitis C NS3/4A protease inhibitor)
A recent letter in ACS Med.Chem.Lett. details the optimisation of a series of inhibitors of the Hepatitis C virus (HCV) NS3/4A protease, and is interesting in that it provides detailed pharmacokinetic data for a series of macrocyclic lactones, a class of therapeutic … Continue reading
Posted in Clinical Candidates, Enzyme Inhibitors, Med Chem Strategy
Tagged animal PK, anti-viral, BILN-2061, Boceprevir, Boehringer Ingelheim, cardiotoxicity, Ensemble Therapeutics Corp., HCV, Hepatitis C, macrocyclic lactone, Merck, MK-1220, MK-7009, NS3/4A, PEG-intron, pegasys, protease, ribavirin, rule of five, SCH 503034, Schering-Plough, Telaprevir, Vaniprevir, Vertex, VX-950
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