-
Join 92 other subscribers
-
Recent Posts
Top Rated
Most Popular:
- Improving Solubility using X-ray crystal structure data
- MDM2-p53 protein-protein interaction inhibitors
- GPCR structure and modeling
- Drug discovery approaches to minimise drug induced liver injury in man
- More physicochemical musings & ChEMBL
- Review: Optimizing CNS access
- Review: Bioisosteres in Drug Design
- Discovery of PF-04691502 (PI3K/mTOR dual inhibitor)
- Synthesis: Sulfonylated Pyridines
- Discovery of MK-1220 (Hepatitis C NS3/4A protease inhibitor)
Blogroll
Conferences
Intellectual Property
Journals
MedChem Resources
News
Organic Chemistry Resources
- Abbott
- adverse events
- allosteric
- allosteric inhibitor
- amine basicity
- Analgesic
- animal PK
- anti-viral
- AstraZeneca
- Aurora
- beta-secretase
- bioactivation
- BIRB-796
- Boehringer Ingelheim
- cancer
- cardiotoxicity
- cellular potency
- CGRP
- chloro
- CNS penetration
- computational method
- crystal packing
- CYP450
- Deuterium
- Doramapimod
- FAAH
- Fatty acid amide hydrolase
- fluorine
- free drug
- functional antagonist
- Gly-T1
- gpcr
- hepatotoxicity
- hERG
- immunosuppressant
- isostere
- kinase
- kinetic isotope effect
- Lexicon Pharmaceuticals
- LipE
- Merck
- metabolism
- mTOR
- nitrile
- Novartis
- osteoarthritis
- P-gp
- p38
- Pain
- PF-04457845
- PF-3845
- Pfizer
- Phase I
- Phase II
- Phase III
- POC
- PPB
- protein binding
- PSA
- reactive metabolite
- review
- RG1678
- rheumatoid arthritis
- Roche
- S1P1
- S1PL
- Schizophrenia
- solubility
- Structural alert
- Structure Based Design
- switch pocket
- synthesis
- toxicity
- Transporters
- X-ray data
Categories
Tag Archives: target protein database
Drug discovery approaches to minimise drug induced liver injury in man
The recent literature has seen a flurry of papers describing the issue of, and potential approaches to minimising the incidence of, drug-induced liver injury (DILI) in the clinic. It is well recognised that attrition throughout the development pipeline is often … Continue reading →
Posted in Med Chem Strategy, Toxicology
|
Tagged adverse events, AstraZeneca, bile transport, biliary efflux, cellular toxicity, crabtree effect, Daiichi Sankyo Co., glutathione, GSH, hepatotoxicity, Merck, mitochondrial toxicity, Pfizer, reactive metabolite, target protein database, toxicity, University of Kansas
|
3 Comments
MedChemBuzz 