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Tag Archives: University of Kansas
Drug discovery approaches to minimise drug induced liver injury in man
The recent literature has seen a flurry of papers describing the issue of, and potential approaches to minimising the incidence of, drug-induced liver injury (DILI) in the clinic. It is well recognised that attrition throughout the development pipeline is often … Continue reading →
Posted in Med Chem Strategy, Toxicology
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Tagged adverse events, AstraZeneca, bile transport, biliary efflux, cellular toxicity, crabtree effect, Daiichi Sankyo Co., glutathione, GSH, hepatotoxicity, Merck, mitochondrial toxicity, Pfizer, reactive metabolite, target protein database, toxicity, University of Kansas
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